Generation of Janus-Type Nanoparticles

Abstract

Nanomaterials are assembled at a colloidal substrate in a layer by layer fashion with biomolecules governing the interaction between the layers. This biomolecule-driven nano-assembly platform using encoded solid supports helps the construction of modular nanosystems with complex architectures. In addition, the proposed approach allows fabrication of Janus-type constructions.

Description

Nanomaterials are assembled at a colloidal substrate in a layer by layer fashion with biomolecules governing the interaction between the layers. This biomolecule-driven nano-assembly platform using encoded solid supports helps the construction of modular nanosystems with complex architectures. In addition, the proposed approach allows fabrication of Janus-type constructions.

We have developed a high-throughput method of reliably creating Janus particles and nanoparticle dimers. Tether a nanoparticle to a substrate, attaches another nanoparticle to the available face of the first, detach the dimer from the substrate or repeat the process to add layers of nanoparticles. The resulting dimers can be used as detectors.

Janus particle's asymmetry provides an opportunity to design in desired functionality to nanoparticles. The Janus particles can link (at least) two dissimilar particles. It allows the creation of layer-by-layer self-assembled structures useful for detecting biologicals and other substances at the single-molecule level. The high-yield, high-throughput assembly method produces more than 75% desired species with no laborious purification steps.

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Marketing Information

Market Summary

Janus particle and dimer biosensors are among the molecular diagnostics replacing current rapid microbiological testing. They detect in real time instead of taking minutes to days for other technologies. The unknown need not be labeled, saving valuable time with sample preparation. The low cost of the tests will encourage widespread adoption.

Benefits

Janus particles can be used to construct very sensitive detectors for a number of “unknowns.” They have already detected species in the picomolar concentration range. Some constructs have demonstrated sensitivity to a single base pair mismatch. Several different species may be detected and distinguished with a single system. The detection system does not require labeling of the unknown. The “label” is built in to the detector.

Applications

Generation of a broad range of nanoparticle monomers with controlled anisotropy can be used in a number of applications including targeted drug delivery, microsensor systems, stabilizers of complex media, and nanocomponents in smart displays.

Advantages

The system is simple, modular and allows high throughput fabrication. The assembly is economical and can be performed in an aqueous solution without strenuous environmental controls and laborious purification steps.

Tech Transfer Details

  • 11/9/2011
  • Kimberley Elcess, Ph.D. (631) 344-4151
  • 11/9/2011

Details

  • Patent
  • BNL
  • Exclusive and Non-Exclusive
  • Mathew M. Maye; Dmytro Nykypanchuk; Daniel Van Der Lelie; Oleg Gang
  • 0 : Not Set/Not Applicable


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